Characterization of biologically active antineutrophil cytoplasmic antibodies induced in mice:pathogenetic role in experimental vasculitis
نویسندگان
چکیده
منابع مشابه
Predictive value of antineutrophil cytoplasmic antibodies in small-vessel vasculitis.
OBJECTIVE . The predictive value of antineutrophil cytoplasmic antibodies (ANCA) as markers of clinical activity of small vessel vasculitis is controversial. We reviewed the outcome of patients with ANCA-associated vasculitis from a single center and evaluated the predictive value of ANCA as markers of relapse. METHODS The medical history of all consecutive patients with ANCA-associated vascu...
متن کاملAntineutrophil Cytoplasmic Antibodies in Patients with Pulmonary Tuberculosis
Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...
متن کاملPulmonary Fibrosis in Antineutrophil Cytoplasmic Antibodies (ANCA)-Associated Vasculitis
Pulmonary fibrosis (PF) is an uncommon manifestation observed in patients with antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), particularly microscopic polyangiitis (MPA). While patients with PF associated with AAV seem to e Brun, MD, Philip D, avid Saadoun, MD, PhD patients with PF associated with AAV, fulfilling the American College of Rheumatology criteria and/or Ch...
متن کاملRefractory disease in antineutrophil cytoplasmic antibodies associated vasculitis.
PURPOSE OF REVIEW Induction treatment of antineutrophil cytoplasmic antibodies (ANCA) associated vasculitis (AAV) is not always successful and nonresponding patients are considered refractory. RECENT FINDINGS Refractory disease should be subdefined to the treatment that was received. Cyclophosphamide refractory AAV occurs in up to 5% of patients. Many more patients develop contraindications t...
متن کاملEpitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis
INTRODUCTION Increasing evidence has suggested that linear epitopes of antineutrophil cytoplasmic antibody (ANCA) directed to myeloperoxidase (MPO) might provide clues to the pathogenesis of propylthiouracil (PTU)-induced ANCA-associated vasculitis (AAV). This study mapped epitopes of MPO-ANCA in sera from patients with PTU-induced MPO-ANCA (with or without vasculitis) and primary AAV, aiming t...
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ژورنال
عنوان ژورنال: Arthritis & Rheumatism
سال: 1995
ISSN: 0004-3591,1529-0131
DOI: 10.1002/art.1780381004